The mystery is solved—CatSper is the principal calcium channel activated by progesterone in human spermatozoa
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The mystery is solved--CatSper is the principal calcium channel activated by progesterone in human spermatozoa.
A remarkable advance in sperm physiology has recently been published in Nature. Two groups using patch clamping techniques on human sperm have solved a mystery about the sperm cell that has puzzled both andrologists and those involved in nongenomic cellular signalling for over 20 years. In these papers, Lishko and Strunker independently demonstrate that the universal characteristic effect of pr...
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Mammalian spermatozoa gain competence to fertilize an oocyte as they travel through the female reproductive tract. This process is accompanied by an elevation of sperm intracellular calcium and a membrane hyperpolarization. The latter is evoked by K(+) efflux; however, the molecular identity of the potassium channel of human spermatozoa (hKSper) is unknown. Here, we characterize hKSper, reporti...
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Disruption of the principal, progesterone-activated sperm Ca2+ channel in a CatSper2-deficient infertile patient.
The female steroid hormone progesterone regulates ovulation and supports pregnancy, but also controls human sperm function within the female reproductive tract. Progesterone causes elevation of sperm intracellular Ca(2+) leading to sperm hyperactivation, acrosome reaction, and perhaps chemotaxis toward the egg. Although it has been suggested that progesterone-dependent Ca(2+) influx into human ...
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ژورنال
عنوان ژورنال: Asian Journal of Andrology
سال: 2011
ISSN: 1008-682X,1745-7262
DOI: 10.1038/aja.2011.9